The Physiologic Effects of a Two Day Liquid Diet on Eleven Females

James A. McHale, D.C. Director, Atlantic Regional Osteoporosis Specialists, P.C. Director, Clinical Advisory Board, The Institute of Weight Management and Health

The Physiologic Effects of a Two Day Liquid Diet on Eleven Females

The purpose of this study was to evaluate the physiologic changes that occurred during a forty eight hour period in which the participants replaced their normal food intake with a liquid. The product claims that consumers can "Lose Up To Ten Pounds in Two Days". The data obtained in this controlled clinical study is being made available so that consumers can decide if this type of diet is right for them. All objective data (that which the researchers see and record) was validated by three unbiased observers.

The only subjective data obtained from study participants involved the listing of any adverse effects from use of the product. Headache was experienced by thirty six (36%) percent of participants.

A random pool of eleven females interested in weight loss was selected to evaluate the efficacy and safety of a liquid weight loss product. The average age of participants was 33 years; all were instructed in the use of the product according to directions on the label.

Product ingredients are listed:

Supplement Facts
Serving Size 4 fl oz. (240 ml) 4 capfuls
Servings per Container 8

ItemAmount per Serving% Daily Value
(based on 2000 calorie diet)
Calories 10.0**
Total Fat0.0**
Natural Sugars17.6 gm**
Carbohydrates 16.0 gm**
Proteins 60.0 mg**
Vitamin A4000.0 IU80
Vitamin E24.0 IU80
Vitamin D-3320.0 IU80
Vitamin C48.0 mg80
Niacin16.0 mg80
Vitamin B-21.36 mg80
Thiamine1.2 mg80
Biotin0.24 mg80
Vitamin B-124.8 mcg80
Noni (10:1 Extract)100.0 mg80

Initial weights were obtained using a scale which was calibrated to fifty, one hundred, one hundred fifty, and two hundred fifty pounds. Beside weight, participants were tested using bioimpedence technology which generated the following data exactly forty eight hours after the start of the program:

A. Metabolic Rate (calories per day)
B. Lean Weight (pounds) **Lean weight is all body structures minus fat. This data accurately reflects muscle mass status.
C. Total Body Water (liters)
D. Water Percent of Lean Weight
E. Percent Body Fat
F. Total Fat Weight (pounds)

Decreases or adverse effects were observed regarding metabolic rate (the amount of calories the human body burns for energy at rest):

1. Average metabolic rate was reduced an average of 48 calories per day.
2. Metabolic rate was reduced an average of 3.3%.

Decreases or adverse effects were observed regarding lean weight:

1. Lean weight dropped an average of 4.65 pounds.
2. Lean weight loss accounted for a 4.1% decrease in body weight.

Decreases or adverse effects were observed regarding body hydration:

1. Total body water was reduced 0.97 liter (one liter weighs approximately 2.1 pounds)

Overall body fat increased an average of 0.3%; many researchers consider this clinically insignificant.

Positive outcomes were observed regarding fat loss.

1. The average amount of fat loss experienced was 4.9 pounds.
2. Total fat loss as a group was 53.6 pounds.


All study participants experienced weight loss. Obviously, fat loss in many consumers is a desired goal. However, even though the average fat loss was 4.9 pounds, they also lost an average of 4.65 pounds of lean body weight. Lean body weight helps determine our metabolic rate; as lean muscle mass increases, so does the metabolic rate. We saw a significant decrease in the metabolic rate of study participants. In just forty eight hours, the participants also experienced an average loss of two pounds of fluid (.97 liter), and their complaints were consistent with people experiencing dehydration.(headache, dizziness, dry mouth, and fatigue). Proper hydration is essential to any safe and healthy weight loss plan. Since so many untoward effects were evident during this study, it is our opinion that consumers should avoid liquid two day diets.

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